Chemistry

AAP Research Notes on Chemistry

Medicinal Chemistry with Pharmaceutical Product Development
Editors: Debarshi Kar Mahapatra, PhD
Sanjay Kumar Bharti, PhD

Medicinal Chemistry with Pharmaceutical Product Development

Published. Available now.
Pub Date: February 2019
Hardback Price: see ordering info
Hard ISBN: 9781771887106
Paperback ISBN: 978-1-77463-409-7
E-Book ISBN: 9780429487842
Pages: 400pp w/Index
Binding Type: hardbound / ebook / paperback
Series: AAP Research Notes on Chemistry
Notes: 11 color and 54 b/w illustrations


Reviews
“This book focuses on novel therapeutics and strategies for the treatment and/or management for various human ailments. I am delighted to read this book, which encompasses various principles and applications associated with medicinal chemistry and pharmaceutical product development. It integrates insights of drug discovery and development through various pharmacological aspects of products, druggable targets of drug candidates and approaches, including nanomedicines. The book will be useful for students, researchers, scientists, and teachers working in cutting-edge research in pharmaceutical technology.”
—From the Foreword by G. S. Singh, PhD, FISCA Professor, Chemistry Department University of Botswana Gaborone, Botswana


Now Available in Paperback


The volumeMedicinal Chemistry with Pharmaceutical Product Development focuses on novel therapeutics and strategies for the development of pharmaceutical products, keeping the drug molecule as the central component. It helps to keep readers abreast of knowledge related to current theoretical and practical aspects of pharmaceuticals for the discovery and development of novel therapeutics for current health problems. Explaining the necessary features essential for pharmacological activity, the book takes an interdisciplinary approach by including a unique combination of pharmacy, chemistry, and medicine along with clinical aspects. The book takes into consideration the therapeutic regulations of the USP (United States Pharmacopeia) along with all the latest therapeutic guidelines put forward by WHO (World Hunger Organization) and the U.S. Food and Drug Administration.

The book provides a broad exposure to the essentials of pharmaceutical chemistry, and more specifically, it explores proteins as drug targets, PTP-1B inhibitors for the treatment of diabetes, Hsp90 inhibitors as anticancer agents, natural products as anti-glycating agents, nanomedicine, nanocarriers, diagnostic devices, and stem cell research and therapy.

The field of medicinal chemistry is growing at an unprecedented pace, and this volume takes an interdisciplinary approach to the topic, covering a range of new research and developments in the field. It will be a valuable resource for professionals and students in pharmaceutical chemistry and product development.

CONTENTS:
Preface

1. Protein Function as Cell Surface and Nuclear Receptor in Human Diseases
Urmila Jarouliya and Raj K. Keservani

2. Islet Transplantation in Type 1 Diabetes: Stem Cell Research and Therapy
Parveen Parasar and Vivek Singh

3. Novel Anti-Cancer Drugs Based on Hsp90 Inhibitory Mechanisms: A Recent Report
Sayan Dutta Gupta

4. Nanosuspensions as Nanomedicine: Current Status and Future Prospects
Shobha Ubgade, Vaishali Kilor, Abhay Ittadwar, and Alok Ubgade

5. Nano Carrier Technologies for Enhancing for Solubility and Dissolution Rate of API
Ashwini Deshpande and Tulshidas S. Patil

6. Recent Perspectives of Chalcone-Based Molecules as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors
Debarshi Kar Mahapatra, Sanjay Kumar Bharti, and Vivek Asati

7. Briefing Therapeutic Approaches in Anticoagulant, Thrombolytic, and Antiplatelet Therapy
Kuntal Manna and Manik Das

8. Insulin Therapy for Diabetes: Current Scenario and Future Perspectives
Yogesh A. Kulkarni, Mayuresh S. Garud, and R. S. Gaud

9. Emerging Potential of in Vitro Diagnostic Devices: Applications and Current Status
Swarnali Das Paul and Gunjan Jeswani

Index


About the Authors / Editors:
Editors: Debarshi Kar Mahapatra, PhD
Assistant Professor, Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India

Debarshi Kar Mahapatra, PhD, is currently Assistant Professor in the Department of Pharmaceutical Chemistry at Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India. He was formerly Assistant Professor in the Department of Pharmaceutical Chemistry, Kamla Nehru College of Pharmacy, RTM Nagpur University, Nagpur, India. He has taught medicinal and computational chemistry at both the undergraduate and postgraduate levels and has mentored students in their various research projects. His area of interest includes computer-assisted rational designing and synthesis of low molecular weight ligands against druggable targets, drug delivery systems, and optimization of unconventional formulations. He has published research, book chapters, reviews, and case studies in various reputed journals and has presented his work at several international platforms, for which he has received several awards by a number of bodies. He has also authored the book titled Drug Design. Presently, he is serving as a reviewer and editorial board member for several journals of international repute. He is a member of a number of professional and scientific societies, such as the International Society for Infectious Diseases (ISID), the International Science Congress Association (ISCA), and ISEI.

Sanjay Kumar Bharti, PhD
Assistant Professor, Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, India

Sanjay Kumar Bharti, PhD, is an Assistant Professor at the Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, India. He has working experience in several organizations, such as Win-Medicare Pvt. Ltd, Meerut, India (as a chemist) and the National Institute of Pharmaceutical Education and Research (NIPER), Hajipur (as a lecturer). He has published several research papers, one book, several book chapters, and several review articles in various reputed journals. His research interest includes synthesis of Schiff’s base, heterocyclic compounds, and metallopharmaceuticals for therapeutics. He is an active member of various scientific and pharmaceutical organizations, like the Indian Pharmaceutical Association, Indian Pharmacy Graduates’ Association, Indian Science Congress Association, among others. Dr. Bharti has received his BPharm degree from Indian Institute of Technology (IIT-BHU), Varanasi, his MPharm degree from Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India, and his PhD from IIT-BHU, Varanasi, India.




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