Pharmaceutical Science & Technology

Inflammatory Bowel Disease and Gut Microbiota
Current Strategies and Future Prospects in Nanomedicine

Editors: Neeraj Mishra, PhD
Sumel Ashique
Ashish Garg, PhD

Inflammatory Bowel Disease and Gut Microbiota

In Production
Pub Date: Forthcoming December 2024
Hardback Price: $249 US | £200 UK
Hard ISBN: 9781774919361
Pages: Est. 655pp w/index
Binding Type: Hardback / ebook
Notes: 10 color and 53 b/w illustrations

Inflammatory bowel disease (IBD) is an umbrella term for immune response-mediated chronic remission and relapse bowel diseases that result in the chronic inflammation of intestines, causing pain and swelling. Although there is no effective cure to date, there has been extensive research on IBD and gut microbiota that has led to insights that may result in effective therapeutic interventions. This new volume, Inflammatory Bowel Disease and Gut Microbiota: Current Strategies and Future Prospects in Nanomedicine, delves into the intricacies of this research, highlighting the novel methodologies and innovative approaches in the treatment of IBD in conjunction with the role of gut microbiota.

The book provides a comprehensive investigation of IBD, exploring the significance of gut microbiota in the advancement and progression of IBD. It investigates the fundamental role of microbial imbalances in the initiation and progression of inflammatory processes, as well as the prominent therapeutic consequences of restoring microbial homeostasis in the context of treatment techniques. The book explores nanotechnology and nanomedicine as a promising field in this regard. It provides a detailed overview of nanotechnological advancement for specific and efficient treatments for IBD. From nanoparticle-based drug delivery systems that advance the bioavailability of the medicaments to the use of bio-nanosensors for early detection of disease, the book covers a broad spectrum of inventions that hold potential for revolutionizing IBD treatment. The authors look at the impact of nutraceuticals, probiotics, prebiotics, functional foods, oral siRNA-based nanomedicine, and other novel drug delivery systems on gut microbiota for the management of IBD. The book also explores the role of reactive oxygen species (ROSs), superoxide dismutases (SODs), and inflammation in association with gut microbiota and IBD. The volume also anticipates future expansions, engaging in speculation on probable progresses and the obstacles that may be confronted.

Aiming to stimulate further research and collaboration across interdisciplinary channels and encouraging a better understanding of IBD, this book will prove beneficial to researchers, clinicians, students, and anyone interested in the intersection of gastroenterology, microbiology, and nanotechnology for the exploration of the current landscape and future potential of treating inflammatory bowel disease.

CONTENTS:
Preface

1. Introduction to Gut Microbiota and Inflammatory Bowel Disease: A Systematic Review

Rukshana Irani, Aniruddha Sen, Jagriti, and Ayan Chatterjee

2. Pathogenesis of Gut Microbiota in Inflammatory Bowel Disease (IBD)
Kuttiappan Anitha, Santenna Chenchula, Shvetank Bhatt, Naveen Kumari Kopineni, Chikatipalli Radhika, and Krishna Chaitanya Amerneni

3. Impact of Nutraceuticals on Gut Microbiota for the Management of IBD
Ushasi Das, Monika Kaushik, Neeraj Mishra, Himanshu Sharma, Subhajit Mandal, Popat Mohite, Aritra Banerjee, Farzad Taghizadeh-Hesary, Radheshyam Pal, Raju Kundavaram, and Sumel Ashique

4. Targeting Gut Microbiota with a Novel Drug Delivery System to Treat Inflammatory Bowel Disease (IBD)
Pavani Sriram, Shvetank Bhatt, and Ashish Suttee

5. Management of Gut Microbiota-Derived Bacterial Metabolites-Induced IBD
Monika Vishwakarma, Poornima Agarwal, Md. Faheem Haider, Tanweer Haider, and Vandana Soni

6. Correlation Between Host Genetics and Gut Microbiota in (IBD)
Manish Kumar, Vir Vikram Sharma, Subh Naman, Abhishek Tiwari, and Varsha Tiwari

7. Oral siRNA-Based Nanomedicine for the Treatment of IBD
Upadhyay S., Soni S., Shukla T., and Pandey S. P.

8. Site-Specific Targeted Novel Drug Delivery System for the Management of IBD
Piyush Singhal, Nusrat Khan, Ravi Verma, and Kantrol Kumar Sahu

9. Surface-Modified Lipid Nanoparticle-Mediated Site-Specific Drug Delivery for IBD
Ankita Dadwal and Bhupinder Kumar

10. Interplay Between Autophagy, Gut Microbiota, and IBD
Arghya Kusum Dhar, Dilipkumar Reddy Kandula, and Narahari N. Palei

11. Role of Reactive Oxygen Species (ROSs), Superoxide Dismutases (SODs), and Inflammation in Association with Gut Microbiota and IBD
Md. Khokon Miah Akanda, Sanzia Mehjabin, A. H. M. Nazmul Hasan, and G. M. Masud Parvez

12. Composition of Gut Microbiota Dysbiosis and Functional Food to Treat Inflammatory Bowel Disease (IBD)
Ashish Garg, Sumel Ashique, Vishal Singh, Gopal Rai, Vijay Sagar Madamsetty, Neeraj Mishra, Naveen Sharma, and Shubneesh Kumar

13. Age-Related Gut Dysbiosis and Its Impact on IBD
Sagnik Nag, Arghyadeep Bhattacharjee, Purva Suhas Shirke, Rhujuta Anand Joshi, Aparajita Bagchi, Rashmi Pejakala Raveendra, and Oindrilla Mukherjee

14. Impact of Diseased Condition on Gut Microbiota in IBD
Sabiha Naz, Shweta Singh, and Tanushree Chaterjee

15. Role of Probiotics and Prebiotics in IBD
Pankaj Sharma, Wasim Akram, Navneet Garud, and Mukul Tailang

16. Application of Natural Products in Targeting Gut Microbiota for IBD Management
Andleeb Rehman, Nihad Ashraf Khan, Saliha Rizvi, and Gowhar Rashid

17. Future Prospects and Patents of Nanomedicines in Treating Inflammatory Bowel Disease
Londhe Sachin Bhimrao, Paul Gajanan Balaji, Amit Kumar, Rupsee Jain, and Awesh K. Yadav

Index



About the Authors / Editors:
Editors: Neeraj Mishra, PhD
Professor, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, MP, India

Neeraj Mishra, PhD, has been working as Professor at the Amity Institute of Pharmacy, Gwalior, India, since July 2019. He has 20 years of teaching and research experience. He was a brand ambassador at Bentham Science, USA, from 2018–19 and has also guided 30 MPharm students and one PhD student to date. He has more than 100 publications in journals of international and national repute on recent concepts of novel drug delivery systems, oral delivery of synbiotics, localized drug delivery, targeted and controlled drug delivery of nanocarriers/microparticles for the treatment of breast and colon cancer, and neurodegenerative disorders. He has also written more than 15 books and 25 book chapters for Elsevier, Bentham, Springer, and John Wiley publications. Dr. Mishra has been granted three international patents and three Indian patents. Dr. Mishra was recipient of an Indian Council of Medical Research Senior Research Fellowship and a Distinguished Professor Award in 2019 from the Indian Department of Science and Technology, National Science and Technology Management Information System, Synergizing Pharma Academic-Industry Collaboration Systems. Dr. Mishra has also received an Outstanding Scientist Award 2020 at the 6th International Scientist Awards on Engineering, Science, and Medicine; a Distinguished Professor Award 2021 from the Indian Pharmaceutical Association, MP State Branch, Indore; and a Best Academician Award from the Indian Pharmacy Graduate Association, M.P. State International Conference. He also received a M.P. Council of Science & Technology project titled, “Dual Functional Colon-Targeted Tofacitinib and Probiotics Loaded Microparticles for the Treatment of Inflammatory Bowel Disease.”

Sumel Ashique
Assistant Professor, Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur, West Bengal, India

Sumel Ashique is an Assistant Professor at Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur, West Bengal, India. He has three years of teaching experience. He has made over 60 publications in international and national accredited reputed journals (Scopus, UGC). He is knowledgeable in drug delivery, nanotechnology, and targeted treatment strategy. He has been granted four patents from IP Australia, has six published chapters in international books, and has submitted 12 more to well-known publishers such as Springer, Elsevier, Bentham, and Taylor & Francis. Currently, he is editing five books under CRC Press, Taylor and Francis, Wiley, and Springer.

Ashish Garg, PhD
Professor, Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy), Jabalpur, M.P., India

Ashish Garg, PhD, is working as Professor at the Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy), Jabalpur, M.P., India. He has around ten years of teaching and research experience. He has 80 publications in national and international journals of repute. He has authored 27 book chapters and edited a few books on recent concepts of nanotechnology, novel drug delivery systems, cancer targeting, etc. Dr. Garg has been granted three international patents and has published three Indian patents. He also acts as an editorial board member and reviewer for several journals.




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