Pharmaceutical Science & Technology

Flavonoids for Neurological Disorders
Advances and Future Prospects

Editors: Rishabha Malviya, PhD
Kamla Pathak, PhD
Shraddha Dwivedi, PhD
Sonali Sundram, MPharm

Flavonoids for Neurological Disorders

In Production
Pub Date: Forthcoming January 2025
Hardback Price: $290 US | £230 UK
Hard ISBN: 9781774919620
Pages: Est. 745pp w/index
Binding Type: Hardback / ebook
Notes: 16 color and 49 b/w illustrations


Reviews
“A thorough compilation painstakingly put together by editors Dr. Rishabha Malviya and Dr. Kamla Pathak. This book provides an important source of understanding about an expanse of prospective remedies in which neurological illnesses pose more complicated obstacles to human health and well-being. . . . Brings readers through the complex world of flavonoids. The introductory chapters of the book explore the underlying chemistry, sources, and biological functions of flavonoids. The subsequent subsequent explores sophisticated extraction methods, categorization, and possible health advantages. As the book progresses, it delves deep into neurological illnesses, revealing how flavonoids may be crucial in the fight against neurodegenerative diseases.”
—From the Foreword by Dr. Prabhat Kumar Singh, Vice Chancellor, Uttar Pradesh University of Medical Sciences, Uttar Pradesh, India


Flavonoids are bioactive phytonutrients found mainly in plants and have the potential to treat a number of ailments, including neurological disorders. This new volume, Flavonoids for Neurological Disorders: Advances and Future Prospects,provides readers with an insightful overview of flavonoids and how they can be used to treat neurological conditions. It presents an in-depth analysis of the interesting link between neurological research and flavonoids.

The book addresses a wide variety of topics, from the basic concepts of flavonoid chemistry, such as taxonomy, sources, chemistry, biological characteristics and extraction techniques, to the exploration of their mechanisms of action in the complex brain structure. The chapters explore various aspects of flavonoid research, starting with an outline of their biological properties, structures, and origins, and moving on to their classification, extraction methods, and potential health benefits. The book also focuses on specific neurological issues, examining how flavonoids may provide therapeutic alternatives for conditions such as dementia, Parkinson’s disease, and Alzheimer’s.

The several roles that flavonoids play in brain aging, synaptic plasticity, and neuroinflammation are also covered in this book. It also sheds light on the intricate signaling pathways that flavonoids use to interact with many brain systems, perhaps offering protection and resistance to degenerative processes. The potential of some flavonoid substances, like kaempferol and cyanidin, to combat oxidative stress and function as neuroprotective agents are also covered in detail. A theoretical perspective offered in chapters comparing flavonoid derivatives serves as an example of this novel approach to understanding their molecular mechanisms of action.

Providing a comprehensive overview of the intricate interactions between natural substances and the complex environment of neurological health, this book will prove engaging for experts as well as inquisitive readers and promotes a thorough understanding of the potential of flavonoids in transforming the field of neurological therapies.

CONTENTS:
Preface

1. Source, Chemistry, and Extraction Methods of Flavonoids

Innocent Mary Ifedibaluchukwu Ejiofor, Christabel Chikodi Ekeomodi, and Mary Ololade Akinlade

2. Introduction and Classification of Flavonoids
Sharda Sambhakar, Bishambar Singh, Samriti Faujdar, and Bhawana Sati

3. Extraction Methods for Flavonoids Using Advanced Techniques
Rosa Isela Guzmán-Gerónimo, Isela Santiago-Roque, Micloth López Del Castillo Lozano, Carmen Bulbarela-Sampieri, and Rafael Fernández-Demeneghi

4. Health Benefits of Flavonoids: A Review
Athira. E, Shinta Davis, Sofia Rachel, and Vijisha. K. Rajan

5. Potential Role of Flavonoids Against Dementia and Alzheimer’s Disease
Salkiæ Adna, Badnjeviæ Meliha, Koriæ Emina, And Gušiæ Irma

6. Flavonoids and Synaptic Plasticity in the Central Nervous System: Mechanisms and Therapeutic Implications
Sijina K. P. and Rajanikant G. K.

7. Flavonoids and the Aging Brain: Insights into Mechanisms and Therapeutic Potential
Navami Krishna and Rajanikant G. K.

8. Flavonoids as a Natural Approach to Alleviate Neuroinflammation and Improve Neurological Health
Lubna M. A. and Rajanikant G. K.

9. Interaction of Flavonoid with Neural Signaling Pathways for Neural Protection
Anmol Saxena, Rishabha Malviya, and Vinod Kumar Tiwari

10. Potential Role of Flavonoids Against Parkinson’s and Huntington’s Disease
Suraj Kumar, Rishabha Malviya, and Vinod Kumar Tiwari

11. Curcumin as a Neuroprotective Agent
Naureen Rizvi, Mohd Muazzam Khan, and Usama Ahmad

12. Cyanidin as a Potential Flavonoid for Curing Oxidative Stress in Biological Systems
Shinta Davis, Vijisha. K. Rajan, Athira E., and K. Muraleedharan

13.Naringenin as a Potential Flavonoid for Neurological Disorders
Neenu Krishna P.U and Muraleedharan K.

14. Methods for Extraction and Analysis of Flavonoids in Common (Fagopyrum esculentum Moench) and Tartary (Fagopyrum tataricum L.) Buckwheat and Their Products
Amela Džafiæ, Enisa Omanoviæ-Miklièanin, and Sanja Oruèeviæ Žuljeviæ

15. Kaempferol as a Neuroprotective Agent
Harsh Yadav, Rishabha Malviya, and Niranjan Kaushik

16. Exploring the Properties of Curcumin as a Multifunctional Neuroprotective Agent: A Therapeutic Insights with Mechanism of Action
M. A. Jaseela and K. Muraleedharan

Index


About the Authors / Editors:
Editors: Rishabha Malviya, PhD
Associate Professor, Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, India

Rishabha Malviya, PhD, has 11 years of research experience and is presently working as Associate Professor in the Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, India. His areas of interest include formulation optimization, nanoformulation, targeted drug delivery, localized drug delivery, and characterization of natural polymers as pharmaceutical excipients. He has authored more than 150 research/review papers for national/international journals of repute. He has over 50 patents to his name and many publications in reputed national and international journals (with a total of 91 cumulative impact factor). He received an Outstanding Reviewer Award from Elsevier. He has edited books (Wiley, Springer Nature, CRC Press/Taylor and Francis, Apple Academic Press, River Publisher, Lambert, etc.) and authored 15 book chapters. His name has been included in the Stanford University’s World’s Top 2% Scientists, 2020 by Elsevier BV and Stanford University. He is reviewer, editor, and editorial board member of more than 50 national and international journals. He was an invited author for the magazine >i>Atlas of Science as well as a pharma magazine dealing with the B2B industry, Ingredients South Asia.

Kamla Pathak, PhD
Dean and Professor, Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Etawah, India

Kamla Pathak, PhD, is Dean and Professor, Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Etawah, India. With teaching and research experience of more than 30 years, she is actively engaged in research on oral controlled, modulated, and targeted and topical drug delivery systems, and has received many awards for her work. She has over 270 publications in journals of international and national repute. She also holds three patents and has authored four books and more than 20 book chapters. She has also written many abstracts in various scientific forums and has been a reviewer for national and international journals in pharmaceutics. Professor Pathak has served as a member of the editorial advisory board of AAPS PharmSciTech and is also a member of various professional bodies. She has guided more than 120 PhD and postgraduate students. She is also associated with the Indian pharmaceutical industry in the capacity of a scientific consultant. She is credited as a reviewer of several scientific projects including Knowledge Foundation, Sweden, and Israel Science Foundation. She has participated at national and international seminars and conferences as organizer, invited speaker, and chairperson of scientific sessions. She has been listed in the top 2% Indian scientists in the subsection Pharmacology and Pharmacy, in the World’s Top 2% Scientists list released by Stanford University in 2020 and 2021. She graduated (Pharmaceutics) from the University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India, earning her doctorate in Pharmacy in 1991 from the same institute.

Shraddha Dwivedi, PhD
Head, Assistant Professor, Department of Zoology, Government Degree College, Haripur, Nihastha, Raebareli, Uttar Pradesh, India

Shraddha Dwivedi, PhD, is currently employed as Head and Assistant Professor in the Department of Zoology, Government Degree College, Haripur, Nihastha, Raebareli, Uttar Pradesh, India. The topic of her research work was “Anti-oxidative and suppressive potential of certain flavonoid plant extracts against As (lll induced genotoxic stress in the fish Channa punctatus (Bloch).” She has a strong academic background with 10 years of research experience. She has authored several research articles published in high impact journals and has presented research papers in seminars and conferences. She has also received a best poster award at the Indian Science Congress held in Mumbai. She has edited one book and authored three book chapters with national and international publisher (Apple Academic Press). She has also received a Congress of Zoology Medal for outstanding research and academic contribution in the field of fish and fisheries by the Zoological Society of India.

Sonali Sundram, MPharm
Assistant Professor, School of Medical & Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh India

Sonali Sundram, MPharm, is Assistant Professor in the School of Medical & Allied Sciences at Galgotias University, Greater Noida, Uttar Pradesh, India. Previously, she worked as a research scientist on a project of the Indian Council of Medical Research at King George’s Medical University, Lucknow, India. After that, she joined BBDNIIT (Babu Banarasi Das Northern India Institute of Technology), Lucknow. Her PhD (Pharmacy) work is in neurodegeneration and nanoformulation. Her areas of interest include neurodegeneration, clinical research, and artificial intelligence. She has edited four books (Wiley, CRC Press/Taylor and Francis, River Publisher) and has organized more than 15 national and international seminars, conferences, and workshops. She has more than eight patents, both national and international, to her credit.




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