Pharmaceutical Science & Technology

Clinical Potential of Exosomes
Diagnostic and Therapeutic Insights

Editor: Vivek P. Chavda, PhD

Clinical Potential of Exosomes

In Production
Pub Date: Forthcoming February 2025
Hardback Price: $260 US | £210 UK
Hard ISBN: 9781774919828
Pages: Est. 798pp w/index
Binding Type: Hardback / ebook
Notes: 21 color and 49 b/w illustrations


Reviews
“Explores one such marvel of nature: exosomes . . . This book is a testament to the collaborative efforts of researchers, clinicians, and innovators who have dedicated their lives to unravelling the mysteries of exosomes. It serves as a beacon of knowledge, illuminating the path forward for scientists, physicians, and students who seek to harness the incredible potential of these tiny vesicles for the betterment of human health.”
—From the Foreword by Vasso Apostolopoulos, Professor Immunology, Institute for Health and Sport, Victoria University, Melbourne, Australia


One of the most significant discoveries in the field of immunology and medicine in recent times is the enigmatic realm of exosomes. Exosomes, which range in size from 30 to 150 nm, are a specific type of extracellular vesicles that are released by nearly all cells. Over the past decade, there has been a significant increase in the detection and understanding of exosomes and how they can be incorporated into the development of innovative therapeutic applications, as well as their role in diagnostic assessments and pathophysiological mechanisms.

This new volume, Clinical Potential of Exosomes: Diagnostic and Therapeutic Insights, explores the diverse roles and features exhibited by cells based on their origin, delving into the intricate mechanisms that govern exosome biogenesis and cargo loading and shedding light on their roles as molecular couriers. The authors discuss valuable insights that exosomes provide on modified cellular or tissue conditions in diverse disorders, and how their identification in biological fluids holds the possibility for a comprehensive diagnostic assessment involving multiple components. The book looks at how the effective transfer of cellular constituents via exosomes can provide valuable insights for the development of exosome-mediated therapies.

The significant and diverse potential of exosomes and extracellular vesicles in the context of managing and combatting various diseases and health are discussed, such as for site-specific drug delivery and vaccine delivery; for cancer management, for the treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, dermal ailments, and ophthalmic ailments; in reproductive medicines; and in regenerative medicines as well as gene therapy and personalized care. A chapter also addresses the regulatory aspects and concerns regarding exosome-based drug delivery.

Covering a wide realm of topics on extracellular vesicles, this book provides an in-depth understanding of the multifunctionality of exosomes that has created novel opportunities for precision medicine, providing individualized strategies for the detection, therapy, and surveillance of many medical conditions. This book will be a valuable reference book for researchers, industry professionals, faculty, and students.

CONTENTS:
Foreword by Vasso Apostolopoulos

Preface

1. Overview of Extracellular Vesicles

Pankti C. Balar, Vladimir N. Uversky, Jimil Gandhi, Karishma Prajapati, and Vivek P. Chavda

2. Genesis of Extracellular Vesicles: Insight to a Complex Ecosystem
Devesh U. Kapoor, Mona R. Kukkar, Mansi Gaur, Vineet Jain, Sudarshan Singh, and Rupesh K. Gautam

3. Isolation and Purification of Extracellular Vesicles
Salwa and Lalit Kumar

4. Engineered and Surface Modified Exosomes: Site-Specific Drug Delivery
Bedanta Bhattacharjee, Sandhanam K., Rajashri Bezbaruah, Ram Kumar Sahu, Niva Rani Gogoi, Tamilanban T., Damanbhalang Rynjah, Gamal Osman Elhassan, Dhunusmita Barman, and Vivek P. Chavda

5. Drug Loading in Exosomes
Pankti C. Balar, Vasso Apostolopoulos, Keval Prajapati, Zahabiya Vaghjipurwala, and Vivek P. Chavda

6. Exosomes and Other Extracellular Vesicles: Process, Design, and Characterization
Chandni Vora, Dharmista Agrawal, Pankti C. Balar, Dixa A. Vaghela, Lalitkumar Vora, and Vivek P. Chavda

7. Characterization of Exosome and Other Extracellular Vesicles
Divya Teli, Rudri Khatri, Riyansi Satasia, Vishwa Patel, Dhvani Gala, and Vivek P. Chavda

8. Exosomes and Other Extracellular Vesicles for Diagnostics
Shailvi Soni, Amit Z Chaudhary, Terrick Andey, and Vivek P. Chavda

9. Exosomes and Other Extracellular Vesicles for Cancer Management
Mit Joshi, Disha Shah, Vivek P. Chavda, and Bhoomika M. Patel

10. Exosomes and Other Extracellular Vesicles for Cardiovascular Diseases
Niva Rani Gogoi, Alan Raj, Venessa Nath, Rajashri Bezbaruah, Ranjit Kumar Mahato, Angel Treasa Alex, Bhaskar Mazumder, and Vivek P. Chavda

11. Exosomes and Other Extracellular Vesicles for Neurodegenerative Diseases
Rajashri Bezbaruah, Sheikh Rezzak Ali, Farak Ali, Md Ariful Islam, Shahnaz Alom, Rubina Chowdhury, and Vivek P. Chavda

12. Exosomes and Other Extracellular Vesicles for Infectious Diseases
Kajal P. Baviskar, Shilpa S. Raut, Komal P. Mahajan, Anjali P. Bedse, A. R. Surana, Pankti C. Balar, and Vivek P. Chavda

13. Exosomes and Other Extracellular Vesicles for Reproductive Medicines
Shruti Soni, Aayushi C. Shah, and Vivek P. Chavda

14. Exosomes and Other Extracellular Vesicles for Dermal Ailments
Vivek P. Chavda, Dixa A. Vaghela, B. H. Jaswanth Gowda, Payal P. Dodiya, Achmad Himawan, and Lalitkumar K. Vora

15. Theranostic Applications of Exosomes and Other Extracellular Vesicles
Avinash Khadela, Humzah Postwala, Neha Raghani, Mohammad Kaif A. Mansuri, Yesha Shah, and Vivek P. Chavda

16. Exosomes and Other Extracellular Vesicles-Based Vaccine Delivery
Amol D. Gholap, Pankaj R. Khuspe, Vivek Hala, Vasso Apostolopoulos, and Vivek P. Chavda

17. Exosomes and Other Extracellular Vesicles in Regenerative Medicines
Srivatsa Surya Vasudevan, Tiba Yamin Kandrikar, Nl. Swathi, Muhammad Bilal Shabbir, Neel Vora, Aisha Shabbir, Shaghaf Zahoor, Debankur Dey, Sumana Kundu, Piyush Gondaliya, and Vivek P. Chavda

18. Exosomes and Other Extracellular Vesicles in Gene Therapy and Personalized Care
Geeta Mahalawat, Tarun Virmani, Girish Kumar, Ashwani Sharma, Prachi Saini, Kanika Mangla, and Kamla Pathak

19. Role of Bioinformatics, AI, and ML for Exosomes and Other Extracellular Vesicle-Based Drug Products
Keshava Jetha, Disha Joshi, Mangesh Kulkarni, Usha Desai, and Vivek P. Chavda

20. Regulatory Aspects and Concerns Regarding Exosome-Based Drug Delivery
Aprameya Ganesh Prasad and Vivek P. Chavda

21. Exosomes and Other Extracellular Vesicles for Ophthalmic Ailments
Dixa A. Vaghela, B. H. Jaswanth Gowda, Lalitkumar K. Vora, Thakur Raghu Raj Singh, Hetvi Jani, Devanshi Gohel, and Vivek P. Chavda


Index


About the Authors / Editors:
Editor: Vivek P. Chavda, PhD
Assistant Professor, Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India

Vivek P. Chavda, MPharm, is currently working as an Assistant Professor in the Department of Pharmaceutics and Pharmaceutical Technology at the L. M. College of Pharmacy, Ahmedabad, Gujarat, India. Before joining academia, he served in the biologics industry for almost eight years in research and development with two successful regulatory filings at Lupin Biotech (Pune) and Dr. Reddy's Laboratory (Hyderabad). He has more than 150 national and international publications, nearly 20 book chapters, several books, one patent in progress as well as numerous newsletter articles to his credit. His research interests include development of biologics processes and formulations, medical device development, nano-diagnostics, long-acting parenteral formulations, and nano-vaccines. He earned his BPharm and MPharm degrees (with gold medals) at Gujarat Technological University, Gujarat, India.




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