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Pharmaceutical Science & Technology
The proposed book will comprehensively discuss about the enzymes such as E1, E2, E3 ligases, deubiquitinating enzymes including proteins which control neurodegenerative disease-inducing proteins, but also their potentials as a therapeutic agent for neurodegenerative diseases. Deubiquitinating enzymes regulates toxic proteins inducing neurodegenerative diseases through proteasome signaling, mitophagy, autophagy etc, for the mitigation of brain disorders. In addition to that, we are going to address biological role of the transglutaminases in the neuroinflammation, with particular interest in the molecular mechanisms, which could involve these enzymes in the pathophysiological processes of human neurodegenerative diseases. Further, the proposed book will also be helpful to explore promising therapeutic targets from highly dynamic ubiquitination modification processes. Only a few numbers of molecules will reach to the market after an extensive effort of researcher in clinical trials. Most of the molecules in the market available for neurodegenerative disorders are not targeted specific and showing severe-side effects and toxicity. Acetylcholinesterase inhibitors and glutamate blockers are available to moderate-severe ND. However, poor blood brain barrier (BBB) permeability and neuronal toxicity are the limitations of existing drugs. So, considering the above-mentioned scientific facts, there is need of development of target specific drug delivery for neurodegenerative disorders. So, in the proposed book, we are going to discuss about the novel targets involved in neurodegeneration and summaries all advance research and formulation strategies to target the neurodegenerative disorders for the safe and effective management of neurodegenerative disorders. CONTENTS: About the Authors / Editors: Editors: Dr. Prashant Tiwari, PhD Associate Professor, Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India Dr. Prashant Tiwari, Ph.D., is currently working as an Associate Professor in the Department of Pharmacology at the College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India. He has gained experience of over a decade in the field of teaching and research related to pharmacology. He received his Ph.D. from Siksha O Anusandhan (Deemed to be) University, Bhubaneswar, Odisha, India. He was a regular fellow of the ICMR, New Delhi. India. He has rich teaching and research experience of more than 13 years of experience in working on screening of several drugs and method validation for the effective delivery of drugs towards brain cell. He has gained experience revalidation of the drug induced dyskinesia and evaluation of the effect of benzimidazole derivative on dopaminergic pathway. He also has riches experience on synthesis of benzimidazole derivative and its prolactin inhibitory effect against neuroleptic drug induced hyperprolactinemia. In addition, to that he was actively involved for the evaluation of Neuroprotective effect of Nanoemulsions containing Lepidium sativum oil against Parkinson's disease. Further, he has direct association for the evaluation of Neuroprotective effect of Muntingia Calabura leaf extract against Alzheimer's Disease for which Dr. Tiwari was awarded Dr. P. D. Patil National Award for Best Thesis in Pharmaceutical Sciences-2022 organized by Dr. P. D. Patil National Institute of Pharmaceutical Sciences and Research, Pune. The team is awarded Third position in the subject category Pharmacology. He has published more than 50 quality research papers along with reviews in journals of high repute, h-index 13, i10 index 18 and 730 citations. He has authored 5 books, edited 4 books, co-authored 06 book chapters and filed 7 patents with 2 patents granted. Dr. Tiwari had organised nation e-seminar titled 'Targeted Drug Delivery System Against Neurodegenerative Diseases' Sponsored by Department of Biotechnology (DBT), New Delhi, Ministry of Science and Technology, Government of India. He has also engaged several accolades like the ICMR SRF, CCSTDST travel grant award for research paper publication. He holds the membership of several nationally and internationally recognized bodies of repute like the LASAI, INS, APTI, IPES, SPER, ERDA etc. He has several awards in his recognition such as Dr. P. D. Patil National Award for Best Thesis in Pharmaceutical Sciences-2022, Young Scientist Award, Young Talent Award, and Best Teacher Award. He is a peer reviewer of various international Journals and publishers. He has guided 06 M Pharm students for their dissertations/research projects and 4 Ph.D. students continuing their research work under his guidance out of which one research fellow has submitted PhD thesis. His research areas include Neurodegenerative disorders, drug interaction, PK/PD, and metabolic disorders. Dr. K. Sunil Kumar Professor, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, India Dr. K. Sunil Kumar is currently working as Professor in the College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, India. He has 16 years of experience in teaching. His area of interest is in Neuropharmacology. He has completed his Ph.D. in Pharmaceutical Sciences from JNTU Hyderabad, Telangana. He has 52 research and review publications in his credit. He has 4 books and 3 patents in his credit. He is a professional member of APTI. His area of Interest is Neuropharmacology and Drug interactions. Dr. Kunjbihari Sulakhiya Assistant Professor, Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak (M.P.), India Dr. Kunjbihari Sulakhiya is working as an Assistant Professor at the Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak (M.P.). He has obtained his M.S. (Pharm) and Ph. D. in Pharmacology and Toxicology from the National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India. He has published 17 research papers, 7 review articles and 10 book chapters in reputed peer-reviewed international and national journals and books. He has received 11 awards/fellowships including 6 travel awards to present his research papers at international conferences in the USA, Canada, Japan, France, and Macau. He is a member of various professional societies including the Indian Academy of Neurosciences (IAN), the International Society for Neurochemistry (ISN), Asia Pacific Society for Neurochemistry (APSN), APTI etc. He is serving as an editorial member and reviewer for various reputed journals. His area of research is pre-clinical research in the field of neuropharmacology. |
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