Pharmaceutical Science & Technology

Nanocarriers for Brain Targeting
Principles and Applications

Editors: Raj K. Keservani, MPharm
Anil K. Sharma, PhD, MPharm
Rajesh K. Kesharwani, PhD

Nanocarriers for Brain Targeting

Published. Available now.
Pub Date: August 2019
Hardback Price: see ordering info
Hard ISBN: 9781771887304
Paperback ISBN: 978-1-77463-412-7
E-Book ISBN: 9780429465079
Pages: 542 w/Index
Binding Type: hardbound / ebook / paperback
Notes: 12 color and 72 b/w illustrations

Now Available in Paperback


This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more.

The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

The blood brain barrier (BBB) blocks the passage of certain substances, posing a challenge to effective drug delivery. The volume looks at how to circumvent this dilemma by designing and developing drug delivery carriers that are be able to deliver drugs across the BBB in a safe and effective fashion.

Topics include:
  • carriers for brain targeting
  • challenges of the blood-brain barrier
  • nanotechnology for brain targeting
  • nanocapsules in brain targeting
  • quantum dots for brain targeting
  • liposomes for brain delivery
  • nanogels and nanoemulsions for brain targeting
This volume, with contributions from experience researchers in the field, helps to meet the high demand for new information on novel nanocarriers products for brain targeting around the world.

KEY SELLING POINTS:
  • Explores the blood-brain barrier and how nanocarriers can circumvent that
  • Presents new research on nanotechnology for brain targeting
  • Explores different types of nanocarriers, such as nanocapsules, solid lipid nanoparticles, liposomes, graphene, nanogels, and more

CONTENTS:
Preface

PART I: INTRODUCTION TO CARRIERS IN BRAIN TARGETING
1. Carriers for Brain Targeting: Recent Advances and Challenges
Md. Sahab Uddin and Mst. Marium Begum

2. The Blood-Brain Barrier and Advanced Carriers for Brain Drug Delivery and Targeting
Ali Sadeghinia, Jaleh Barar, Morteza Eskandani, Mohammad A. Rafi, and Yadollah Omidi

3. Nanotechnology for Brain Targeting
Debjani Banerjee, Huma Shamshad, and Nidhi Mishra

4. Nanocarriers for Brain Targeting: An Overview
B. A. Aderibigbe, I. A. Aderibigbe, and A. P. I Popoola

5. Natural Biopolymeric Nanoformulations for Brain Drug Delivery
Josef Jampílek and Katarína Krá?ová

PART II: PARTICULATE CARRIERS
6. Nanoparticulate Drug Delivery Systems for Brain Targeting
Emil Joseph, Gautam Singhvi, and Saswata Banerjee

7. Nanocapsules in Brain Targeting
Soumya Nair and Jayanthi Abraham

8. Solid Lipid Nanoparticles for Brain Targeting
M. M. De Araujo, L. B. Tofani, I. L. Suzuki, P. D. Marcato, and M. V. L. B. Bentley

9. An Introductory Note on Quantum Dots for Brain Targeting
Kirti Rani

10. Graphene for Brain Targeting
S. J. Owonubi, B. A. Aderibigbe, V. O. Fasiku, E. Mukwevho, and E. R. Sadiku

PART III: VESICULAR CARRIERS
11. A Brief Account of Liposomes for Brain Delivery
D. B. Borin and R. C. V. Santos

12. Liposomal Drug Carriers: Principles, Formulation Perspectives, and Potentials for Brain Drug Delivery
Juliana Palma Abriata, Marcela Tavares Luiz, Giovanni Loureiro Raspantini, Patrícia Mazureki Campos, and Juliana Maldonado Marchetti

13. Niosomes for Brain Targeting
Didem Ag Seleci, Muharrem Seleci, Rebecca Jonczyk, Frank Stahl, and Thomas Scheper

PART IV: OTHER ISSUES
14. Nanoemulsions for Brain Targeting
Khushwinder Kaur and Shivani Uppal

15. Nanogels for Brain Targeting: Introduction, Formulation Aspects, and Applications
Nagarjun Rangaraj and Sunitha Sampathi

16. Applications of Nanocarriers in Emerging and Re-Emerging CNS Tropical Infections
S. Yasri and V. Wiwanitkit

Index


About the Authors / Editors:
Editors: Raj K. Keservani, MPharm
Faculty of B.Pharmacy, CSM Group of Institutions, Allahabad, India

Raj K. Keservani, MPharm, is in the Faculty of B. Pharmacy, CSM Group of Institutions, Allahabad, India. He has more than seven years of academic (teaching) experience from various institutes of India in pharmaceutical education. He has published 30 peer-reviewed papers in the field of pharmaceutical sciences in national and international journals, fifteen book chapters, two co-authored books, and two edited books. He is also active as a reviewer for several international scientific journals. Mr. Keservani graduated with a pharmacy degree from the Department of Pharmacy, Kumaun University, Nainital (UA), India. He received his Master of Pharmacy (MPharm) (specialization in pharmaceutics) from the School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India. His research interests include nutraceutical and functional foods, novel drug delivery systems (NDDS), transdermal drug delivery/ drug delivery, health science, cancer biology, and neurobiology.

Anil K. Sharma, PhD, MPharm
Lecturer, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, India

Anil K. Sharma, MPharm, PhD, is working as a lecturer at the Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, India. He has more than six years of academic experience in pharmaceutical sciences. He has published 28 peer-reviewed papers in the field of pharmaceutical sciences in national and international journals as well as 15 book chapters and 10 edited books. He received a bachelor’s degree in pharmacy from the University of Rajasthan, Jaipur, India, and a Master of Pharmacy degree from the School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India, with a specialization in pharmaceutics. He earned his doctorate (PhD) from university of Delhi, Delhi. His research interests encompass nutraceutical and functional foods, novel drug delivery systems (NDDS), drug delivery, nanotechnology, health science/life science, and biology/cancer biology/neurobiology.

Rajesh K. Kesharwani, PhD
Department of Advanced Science & Technology, NIET, Nims University Rajasthan, Jaipur, India

Rajesh K. Kesharwani, PhD, is affiliated with the Department of Advanced Science & Technology, NIET, Nims University Rajasthan, Jaipur, India. He has more than seven years of research and two years of teaching experience in various institutes of India, imparting bioinformatics and biotechnology education. He has received several awards, including the NASI-Swarna Jayanti Puruskar-2013 by The National Academy of Sciences of India. He has authored over 32 peer-reviewed articles and ten book chapters. He has been a member of many scientific communities as well as a reviewer for many international journals. Dr. Kesharwani received a BSc in biology from Ewing Christian College, Allahabad, India, an autonomous college of the University of Allahabad; his MSc (Biochemistry) from Awadesh Pratap Singh University, Rewa, Madhya Pradesh, India; and MTech-IT (specialization in Bioinformatics) from the Indian Institute of Information Technology, Allahabad, India. He earned his PhD from the Indian Institute of Information Technology, Allahabad, and received a Ministry of Human Resource Development (India) Fellowship and Senior Research Fellowship from the Indian Council of Medical Research, India. His research fields of interest are medical informatics, protein structure and function prediction, computer-aided drug designing, structural biology, drug delivery, cancer biology, and next-generation sequence analysis.




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