Medicine & Health Sciences

Metastatic Diseases
Novel Approaches in Diagnosis and Therapeutic Management

Conceived and edited by: Sandeep Arora, PhD
Co-editors:
Tapan Behl, PhD

Sukhbir Singh, PhD
Neelam Sharma, PhD
Saurabh Gupta, PhD

Metastatic Diseases

Published. Available now.
Pub Date: November 2021
Hardback Price: see ordering info
Hard ISBN: 9781771889179
E-Book ISBN: 9781003043249
Pages: 316pp w/index
Binding Type: Hardback
Notes: 11 color and 34 b/w illustrations

Metastatic Diseases: Novel Approaches in Diagnosis and Therapeutic Management opens new horizons for exploring modern therapeutic entities and emerging targets for combating the deadly disease of cancer. The authors provide a review of cancer along with descriptions of its molecular level mechanisms and emphasize the role of promising new therapies, including herbal therapies that can be utilized for the treatment of metastatic diseases.

The chapters look at specific approaches that have been researched and developed and that have almost reached the standardization stage. One of the approaches focuses on intracellular mechanisms, particularly proteins, and the pathway involving or being regulated by the proteins that limit the metastatic cellular growths. In particular phosphoprotein enriched astrocytes are being extensively tried. Also discussed is transerythretin protein, which has been significantly studied for its involvement in formation and transportation of proteins in metastatic diseases. Other receptors and approaches examined include CXCR4, autophagy-inhibiting drugs, phosphoprotein-enriched astrocytes, spatiotemporal genetic analysis, tyrosine kinase inhibitors, and more.

Also considered are advances in diagnostic systems like intra vital microscopy and molecular imaging, which further add to the arsenal in metastatic diseases, diagnosis, and management along with techniques like SAGA. These diagnostic methods and innovative methods of intervention by modification of epigenetic control of the immune system using immune checkpoint inhibitor s and phytopharmaceuticals provide newer and better dimensions to treatment of metastatic diseases.

Key features:

  • Discusses promising new therapies, including herbal therapies, for the treatment of metastatic diseases
  • Explains the new areas that are widely explored by scientists, researchers, and scholars throughout the globe
  • Explores new therapeutic molecules for cancer treatment


The selection of appropriate treatment strategies presented in this volume provide deep insight into the adverse effects and contraindications that will be of immense benefit in the treatment and management of detrimental effects of this deadly disease. The volume will be beneficial for major laboratories working on cancer research and will also serve as a guide for researchers to explore new targets that can be beneficial for mankind.

CONTENTS:
Preface

1. A Review on Cancer: From Clinical Perspective to Chemotherapy
Sandeep Arora and Pooja Sharma

2. Phosphoprotein-Enriched Astrocytes as Potential Anti-Cancer Agents
Sandeep Arora and Nidhi Garg

3. Autophagy-Inhibiting Drugs as Complements to Cancer Chemotherapy
Sandeep Arora and Sukhbir Singh

4. Transthyretin Protein in Renowned Metastatic and Other Conditions
Sandeep Arora, Tapan Behl, and Kiranjeet Kaur

5. Role of CXCR4 Receptor Protein in Cancer Development and Therapies
Sandeep Arora and K. A. Shaima

6. C3d Complement System in Immunotherapy-Based Cancer Treatment
Sandeep Arora, Nidhi Garg, and Pooja Sharma

7. BH3 Mimetics
Sandeep Arora, Sukhbir Singh, and Neelam Sharma

8. Spherical Nucleic Acid Platform Based Drug Delivery for Brain Cancer and Improved Blood Brain Barrier Crossing for Alzheimer’s and Other Diseases
Sandeep Arora, Saurabh Gupta, and Sukhbir Singh

9. Intra-Vital Microscopy: A New Amelioration in Cancer Immunotherapy Monitoring
Sandeep Arora, Neelam Sharma, and Sukhbir Singh

10. Molecular Imaging: A New Advancement in Cancer Immunotherapy Monitoring
Sandeep Arora and Neelam Sharma

11. Spatiotemporal Genetic Analysis (SaGA) Technique for Cancer Cell Biology Studies
Sandeep Arora, Saurabh Gupta, and Neelam Sharma

12. Plant-Derived Anti-Malarial Compounds and Their Derivatives as Anti-Cancer Agents: Future Perspectives
Samir Mehndiratta, Sandeep Arora, and Tapan Behl

13. Epigenetic Control of the Immune System
Sandeep Arora, Sukhbir Singh, Neelam Sharma, Tapan Behl, and Nidhi Garg

14. Immune Check Point Inhibitors
Sandeep Arora, Saurabh Gupta, and Nidhi Garg

15. Tyrosine Kinase Inhibitors in Lymphocytic Leukemia
Sandeep Arora, Tapan Behl, Sukhbir Singh, Neelam Sharma, and Nidhi Garg

16. Cyclooxygenase – 1 (COX-1) Inhibitors in the Management of Neoplastic Disorders
Sandeep Arora, Saurabh Gupta, and Suman

17. Microfluidics Devices in Capturing Circulating Metastatic Cancer Cell Clusters
Sandeep Arora, Ajmer Singh Grewal, Neelam Sharma, and Sukhbir Singh

Index


About the Authors / Editors:
Conceived and edited by: Sandeep Arora, PhD
Director, Chitkara Institute of Pharmaceutical Sciences; Professor, Healthcare Rajpura Campus, in Punjab, India

Sandeep Arora, PhD, is Director of the Chitkara Institute of Pharmaceutical Sciences and Professor, Healthcare Rajpura Campus, in Punjab, India, as well as an industrial consultant. He is a member of the University Academic Committee, Board of Management, and many other committees at the university. He is a member of the National Pharmacy Council of India. He is an honorary editor of the journal Advanced Drug Review(a quarterly drug pharmacology review index), Editor of the Journal of Pharmaceutical Technology, Research and Management, and Honorary Technical Director and Advisor to Natural Solutions, Mumbai. Dr. Arora has experience in both pharmaceutical production planning and management and quality assurance and research and development. To date, he has registered 13 patents and four trademarks, published papers in over 90 international and national publications, and edited three books. He is a PhD doctoral thesis examiner for various universities.

Co-editors:
Tapan Behl, PhD

Associate Professor, Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India

Tapan Behl, PhD, MPharm, is currently working as an Associate Professor in the Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India. Dr. Behl carries professional experience of over eight years in academics and research. His areas of interest include diabetes and associated complications, rheumatoid arthritis, preclinical ethical considerations, molecular pharmacology, pharmacotherapy for diabetic complications of the eye, drug transfusion across ocular barriers, and neuropathic pain and rheumatoid arthritis. Dr. Behl has more than 75 publications in various international and national journals of repute. He is also the author of two international books and has various book chapters to his credit. He has been invited as a guest speaker at various international and national conferences. Dr. Behl represents India as a voting delegate during the IUPHAR meeting and selection of IUPHAR 2026 in Kyoto, Japan. Dr. Behl has received many prestigious honors and awards for his work and academic excellence, including Academician of the Year Award–2018, Fellow of Society of Biomedical Laboratory Scientists, etc. He is also serving as a reviewer of many reputed journals in his field. Dr. Behl is engaged in guiding students for their doctoral (PhD) work.

Sukhbir Singh, PhD
Associate Professor, Chitkara College of Pharmacy, Chitkara University, Punjab, India

Sukhbir Singh, PhD, is an Associate Professor at Chitkara College of Pharmacy, Chitkara University, Punjab, India. He is also Deputy Dean of Industry Oriented Courses held in collaboration with Chitkara University and established pharmaceutical industries. He has over 40 publications in various national and international journal of repute and filed seven patents to date. He has presented or published almost 40 review and research abstracts at various national and international conferences. He is also engaged with four consultancy projects on herbal/homeopathic formulation. He is an associate editor of the Open Access Journal of Pharmaceutical Research. He has guided several MPharm students and several PhD students. His areas of interest in research are nanotechnology-based formulation development and solubility enhancement of BCS class II drugs.

Neelam Sharma, PhD
Associate Professor, Chitkara College of Pharmacy, Chitkara University, Punjab, India

Neelam Sharma, PhD, is an Associate Professor at Chitkara College of Pharmacy, Chitkara University, Punjab, India. She has 35 publications in various national and international journals of repute and has filed six patents. She has presented and published 30 review and research abstracts at various national and international conferences. She is engaged in four consultancy projects on herbal/homeopathic formulations. She has supervised seven MPharm students and one PhD student to date. Her areas of interest in research are novel drug delivery system such as nanoparticle, liposomes, phytosomes and solubility enhancement of BCS class II drugs. She also has expertise in operation of various statistical analyses tools.

Saurabh Gupta, PhD
Associate Head, Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab, India

Saurabh Gupta, PhD, is Associate Head of the Department of Pharmacology at Chitkara College of Pharmacy, Chitkara University, India. His research focuses on asthmatic pharmacology and cellular and molecular biology. He is serving as an editorial member of several reputed journals, including the Austin Journal of Pharmacology and Therapeutics, World Journal of Pharmaceutical Research,and World Journal of Pharmacy and Pharmaceutical Sciences. He is also an expert reviewer for the journals International Immunopharmacology and Journal of Physiology and Pharmacology. He has authored over 30 international and national research articles, two books, and a book chapter. Dr. Gupta is associated with many professionals body, and is a CPCSEA Nominee and an elective member of the Indian Pharmaceutical Association, Madhya Pradesh State Branch, Indore, India.




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