Biomedical Engineering/Nanotechnology

Modern Trends in Molecular Biology

Hematopoiesis
Biochemical, Cellular, Molecular, and Genomic Perspectives

Editor: Ravi Kumar Gutti, PhD

Hematopoiesis

Published. Available now.
Pub Date: January 2024
Hardback Price: see ordering info
Hard ISBN: 9781774914724
E-Book ISBN: 9781003413059
Pages: 318pp w/index
Binding Type: Hardback / eBook
Series: Modern Trends in Molecular Biology
Notes: 19 color and 4 b/w illustrations


Reviews
“An excellent book which describes normal and abnormal hematopoiesis from biochemical, cellular, molecular, and genomic perspectives . . . unique in succinctly and lucidly describing the current information on hematopoiesis. Hematologists, oncologists, scientists, and students interested in thefield of Hematopoiesis will find this book very useful. . . ”
— Doody’s Core Titles, 2024


“Provid[es] an accurate overview of the functional importance of hematopoiesis from different perspectives and the surrounding molecular mechanisms that influence the process of hematopoiesis in one way or another. Extremely pertinent and up-to-date information . . . Highly recommended . . . Sheds light on different factors that indulge and regulate the hematopoietic events. The uniqueness of this book encompasses the myriad of information on the biology of normal and aberrant hematopoiesis, epigenetic factors, and on the research tools to assist in the deeper study of aspects relating to the status of blood cells in cancerous scenario. . . . Some specifics of leukemia/lymphoma governed by various non-conventional molecules are also part of this book.”
—From the Foreword by Prof. Dr. Natália Cruz-Martins, PhD, Cooperativa de Ensino Superior Politécnico e Universitário (CESPU); Faculdade de Medicina, Universidade do Porto (FMUP), Porto, Portugal


This new volume discusses the widespread concerns of hematopoietic challenges in different and emerging ways. With chapters written by faculty from prestigious institutions working directly in hematopoiesis and advanced areas of biology, the volume offers a comprehensive overview of the regulation of blood cell development, epigenetic mechanisms, and regulatory non-coding RNAs. It presents concepts related to regulation of hematopoietic stem cell development, as well as survival, proliferation, and differentiation. It also discusses the microenvironmental niche where stem cells exist and develop into distinct blood cell types. A model system used to study non-coding RNA functions and along with transformation of normal cells into cancer cell is elaborated on as well.

Key features of the book:

  • Details how to utilize the available investigative tools and techniques to isolate and study single blood cells in different model systems
  • Discusses the epigenetics of hematopoiesis
  • Considers the clinical outcomes of defective hematopoiesis
  • Describes hematopoiesis and cancer stem cells
  • Looks at hematopoiesis in relation to specific diseases, such as minimal residual disease (MRD) and leukemia
This book provides valuable information related to developments in hematopoiesis that will be helpful for understanding the basics of hematopoiesis and the clinical treatment of blood diseases. Hematopoiesis: Biochemical, Cellular, Molecular, and Genomic Perspectives will be valuable to clinicians, medical school students, and researchers working in hematology.

CONTENTS:
Foreword by Natalia Cruz-Martins, PhD

Preface

1. Unravelling the Mechanism of Zebrafish Hematopoiesis: A Novel Approach
Aparajita Chakraborty

2. Investigative Tools to Study Blood Cells: Focus on Single Cell Isolation and Analysis
Dushyant Kumar Gautam, Anuradha Venkatakrishnan Chimata, Ravi Kumar Gutti, and Indira Paddibhatla

3. Evaluation of Chitosan and Its Derivatives in Immunomodulating Blood Sentinel Cells
Arun Kumar Subramani, Keyur Raval, and Ritu Raval

4. Proteoglycans and Glycosaminoglycans Regulating Functions of the Hematopoietic Stem Cell Niche
Samiksha Wasnik, Lakshmi Manasa Chaturvedula, and Chaturvedula Tripura

5. Epigenetics of Hematopoiesis: Role of HATs and HDACs
Arunasree M. Kalle and Debasmita Naik

6. Systems Biology Approaches Toward Understanding Human Long Non-Coding RNA Hematopoietic Cells
Swati Dahariya, Sanjeev Raghuwanshi, and Ravi Kumar Gutti

7. Clinical Outcomes of Defective Hematopoiesis
Geeta Rai, Doli Das, Khushbu Priya, and Hiral Thacker

8. Circulating Messengers of Blood and Their Clinical Applications
Rasmita Samal and Anula Divyash Singh

9. Hematopoiesis and Cancer Stem Cells: The Seed and the Soil Crosstalk
Akhilesh Prajapati

10. lncRNAs in Types of Leukaemia
Swati Dahariya, Aditya Velidandi, Dushyant Kumar Gautam, Ravi Kumar Gutti and Indira Paddibhatla

11. Minimal Residual Disease (MRD) as a Prognostic Factor in Acute Myeloid Leukaemia
Anpreet Choudhary, Rekha Sharma, Satti Vishnupriya, Rajender Rao K, Raghunath Manchala, Suvir Singh, Obul Reddy Bandapalli , Prashant Suravajhala, Raghunadharao Digumarthi, and Sugunakar Vuree

Index


About the Authors / Editors:
Editor: Ravi Kumar Gutti, PhD
Professor, Department of Biochemistry, School of Life Sciences, University of Hyderabad, India

Ravi Kumar Gutti is currently working as Professor of Biochemistry, in University of Hyderabad. He obtained his Doctoral degree in the area of Molecular Biology and Biotechnology from New Delhi in 2003. He has received NIH Fogarty fellowship 2004-2008 and Harvard Medical School fellowship 2008-2010 for biomedical training and has guided 7 students for their PhD degrees. He has published 50 research papers in international journals. He has completed 14 major projects and has received many awards such as Innovative Young Biotechnologist Award by DBT (2011), ICMR Tilak Venkoba Rao Award in Physiology (2012), Royal Society Award (UK) for Established Scientists (2017) and Chancellor’s Award of University of Hyderabad (2018) for making significant contributions to teaching and research. Elected as fellow of the Telangana Academy of Sciences (FTAS) for the year 2019 in Medical, Health and Pharmaceutical Sciences.




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