Biotechnology

Forensic DNA Analysis
Technological Development and Innovative Applications

Editors: Elena Pilli, PhD
Andrea Berti, PhD

Forensic DNA Analysis

Published. Available now.
Pub Date: March 2021
Hardback Price: see ordering info
Hard ISBN: 9781771889056
E-Book ISBN: 9781003043027
Pages: 554pp w/ index
Binding Type: Hardback
Notes: 16 color and 47 b/w illustrations


Reviews
“Provide[s] an overview of new technologies and current applications in forensic genetics. It accomplishes this with chapters on genome structure and DNA polymorphisms and the different classes of biomarker types that have current forensic utility. Novel technologies and techniques in forensic genomics are addressed by the authors on topics including MPS, phenotypic traits and bio-geographical ancestry. Pleasingly, the book recognizes that human forensic geneticists do not operate in a vacuum and are not the only people who deal with biological material, and hence, chapters on forensic anthropology, entomology, wildlife forensics, and molecular autopsy of sudden cardiac death are included. Uniquely, a voice is given to a number of commercial vendors with scientific descriptions of their innovative technologies. Prospective readers who would benefit from reading the book, or chapters therein, include forensic geneticists and other forensic specialists who desire up to date reviews on the state of the art in forensic genomics, criminal justice professionals including trial attorneys, and educators and their students.”
—From the Foreword by Jack Ballantyne, University of Central Florida, Orlando, Florida, USA

Forensic DNA Analysis: Technological Development and Innovative Applications provides a fascinating overview of new and innovative technologies and current applications in forensic genetics. Edited by two forensic experts with many years of forensic crime experience with the Italian police and with prestigious academic universities, the volume takes an interdisciplinary perspective. It presents an introduction to genome polymorphisms, discusses, forensic genetic markers, presents a variety of new methods and techniques in forensic genetics, and looks at a selection of new technological innovations and inventions now available from commercial vendors.

Key features:

  • Examines the genome polymorphisms and forensic identity markers
  • Presents new scientific and technological developments in forensic genetics
  • Describes the sequencing technology in forensic science in depth
  • Presents the different fields of application of the new sequencing technology
  • Highlights the importance of physical and molecular methods to solve forensic anthropology issues
  • Looks at forensic genetics issues in criminal justice, ancestry, wildlife, entomology, etc.
The book is an important resource for scientists, researchers, and other experts in the field who will find it of interest for its exhaustive discussion of the most important technological innovations in forensic genetics. For those newer to the field, the volume will be an invaluable reference guide to the forensic world.

CONTENTS:
Foreword by Jack Ballantyne, University of Central Florida, Orlando, Florida, USA

Preface

PART I: INTRODUCTION TO GENOME POLYMORPHISMS
1. DNA Polymorphisms and Genome Structure: Different Scales of Variation in the Human Genome
Andrea Novelletto and Bianca Maria Ciminelli

2. Single Nucleotide Polymorphisms: An Overview of the Sequence Polymorphisms
Eugenia D’atanasio, Fulvio Cruciani, and Beniamino Trombetta

PART II: FORENSIC GENETIC MARKERS
3. Forensic Identity Markers: An Overview of Forensic Autosomal STRs and SNPs
Debora Vergani

4. The Y-Chromosomal STRs in Forensic Genetics: Y Chromosome STRs
Debora Vergani

5. The X-Chromosomal STRs in Forensic Genetics: X Chromosome STRs
Vânia Pereira and Leonor Gusmão

6. Application of Mitochondrial DNA as a Tool in the Forensic Field: Update and New Perspectives in mtDNA Analysis
Manuel Crespillo Márquez, Pedro A. Barrio Caballero, and Carolina Núñez Domingo

PART III: NOVELTIES IN FORENSIC GENETICS
7. Sequencing Technology in Forensic Science: Next Generation Sequencing
Runa Daniel and Sallyann Harbison

8. Forensic Analysis of Externally Visible Characteristics: Phenotyping
Daniele Podini and Katherine B. Gettings

9. Forensic Ancestry Inference: Data Requirements, Analysis Methods, and Interpretation of Results
O?lem Bulbul and Kenneth K. Kidd

10. Online Population Data Resources for Forensic SNP Analysis with Massively Parallel Sequencing: An Overview of Online Population Data for Forensic Purposes
C. Phillips, J. Amigo, D. Mcnevin, M. De La Puente, E. Y. Y. Cheung, and M. V. Lareu

11. Forensic Anthropology Issues: A Synergy Between Physical and Molecular Methods: The Contribution of Degraded DNA Analysis to Physical and Forensic Anthropology
Elena Pilli, Elisa Castoldi, and Cristina Cattaneo

12. The Molecular Autopsy: Complementary Study to Molecular Autopsy
S. Zoppis, A. Blanco-Verea, and M. Brion

13. Wildlife Forensics: DNA Analysis in Wildlife Forensic Investigations
Rita Lorenzini and Luisa Garofalo

14. Forensic Entomology: The Utility of the Insects at Court and in Human Identification
S. Lambiase and A. M. Tarone

PART IV: COMPANY INNOVATIONS
15. Getting the Most Information from Every Sample: Improved Length-Based and Sequence-Based Analysis
Rohaizah I. James

16. Paradna® Technology: A Tool for Rapid Identification of DNA and Body Fluids
Laura Dodd, Stephanie Regan, and Tobias Hampshire

17. Deparray™ System: Key Enabling Technology for Cell Separation from Forensic Mixtures
Roberta Aversa, Francesca Fontana, Gianni Medoro, and Nicol? Manaresi

18. Rapid DNA by Ande Corporation: A Useful Tool for Disaster Victim Identification
Rosemary Turingan Witkowski and Richard F. Selden

19. Massively Parallel Sequencing as an Operational Forensic Tool: Current and Future Perspectives: Improving Results for Current Applications and Paving the Way for Expanded Capabilities
Nicola J. Oldroyd Clark and Cydne L. Holt

Index


About the Authors / Editors:
Editors: Elena Pilli, PhD
Forensic Molecular Anthropologist and Captain of the Italian Military Police “Carabinieri,” Forensic Scientific Centre, Rome, Italy.

Elena Pilli, PhD, is a Forensic Molecular Anthropologist and Captain of the Italian Military Police “Carabinieri” at the Forensic Scientific Centre in Rome, Italy, since 2017, a reserve officer selected by CV for her molecular anthropological competence. Prior to that, she was Head of the Forensic Molecular Anthropology Unit of the Department of Biology at the University of Florence, Italy. She was Professor of Forensic Genetics at the Master School in Technologies and Applications for scientific investigations at the University of Florence. An expert in analysis of DNA extracted from highly degraded samples, such as human and animal bones and teeth and human and animal hair, Dr. Pilli was involved in several important cold cases of national interest. She was also in charge of the identification of the Fallen at the Fosse Ardeatine (a mass grave national case), and she was recently involved in identification of human remains of Strage di Bologna (terroristic attack occurred in 1980). The author of approximately 40 publications in national and international scientific peer-reviewed journals and author of several book chapters, she was recognized for her scientific research for a Science Breakthrough of the Year. She is a reviewer of international journals, such as PLos One, BMC Genetics, and Scientific Reports. Her PhD was earned in biology, anthropology, and primatology. In 2018 she achieved the National Scientific Qualification as Associate Professor in Zoology and Anthropology.

Andrea Berti, PhD
Forensic Biologist and Lgt. Colonel of the Italian Military Police “Carabinieri,” Forensic Scientific Centre, Rome, Italy

Andrea Berti, PhD, is a Forensic Biologist and Lgt. Colonel of the Italian Military Police “Carabinieri” at the Forensic Scientific Centre in Rome, Italy. He has been working in a forensic DNA laboratory since 1997 and has been the Technical Manager of the Forensic Biology Unit since 2010 (accredited ISO:IEC 17025 since 2012). The biology unit works on approximately 1,400 crime cases each year that occur in central and southern Italy, handling about 3,000 items of forensic evidence and performing 20,000 DNA analyses each year. The unit also employs NGS technology for forensic applications. Dr. Berti is certified as a BPA analyst and internal auditor for QA in forensics. He is a member of many professional organizations and is co-author of more than 40 articles published in forensic journals. Since 1999, Dr. Berti has been a trainer to the Italian military academy for forensic crime scene investigation and DNA analysis. He is also involved in managing the Italian DNA database as a CODIS supervisor.




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