Nanotechnology

Engineered Nanomaterials in Biomedical Aspects
Promises, Limitations, and Applications

Editors: Kaushik Pal, PhD
Gharieb Saied Saad El-Sayyad, PhD
Mohamed Abd Elkodous

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Engineered Nanomaterials in Biomedical Aspects

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Nanoparticles engineered for shape, size, and surface properties impart special functionalities including catalytic behavior, improved strength, enhanced thermal and electrical conductivity, and controlled release of host molecules. These advances have opened up applications in biomedicine, nanoenergetic materials, and functional nanocomposites. This book will highlight successes in developing nanoparticles for a number of diverse applications. A field in which nanoparticles are poised to play a significant role is biomedicine. The promise of nanobiomaterials for diagnostic and therapeutic biomedical applications has been widely reported throughout the scientific community, and great strides have been made in those directions. And yet, the translation of nanomaterial-based therapeutics to clinical applications remains an elusive target. The detailed studies in this book have been undertaken to understand fundamental interactions between nanomaterials and the biological environment. In particular, recent developments in nanoparticle synthesis, a better understanding and control over nanoparticle surface chemistry, as well as the organization of that chemistry on the nanoparticle surface, have allowed researchers to begin to understand how spatial arrangement of atomic and molecular species at an interface can affect protein adsorption, structure, and subsequent biological outcomes. This perspective strives to identify ways in which the nanomaterial interface can be controlled to affect interactions with biomolecules for beneficial biomedical applications. The collection of investigations in this special issue highlights the importance of engineered nanoparticles and points to multiple areas in which nanoparticle research has the potential to make new contributions.

Innovative engineered nanomaterials are at the leading edge of rapidly emerging fields of nanobiotechnology and nanomedicine. Meticulous synthesis, unique physicochemical properties, manifestation of chemical or biological moieties on the surface of materials make engineered nanostructures suitable for a variety of biomedical applications. In addition, tailored nanomaterials exhibit entirely novel therapeutic applications with better functionality, sensitivity, efficiency, and specificity due to their customized unique physicochemical and surface properties. Additionally, scientist-made nanomaterials have potential to generate a series of interactions with various biological entities including, e.g. DNA, proteins, membranes, cells culturing, tissue engineering, biosensor and organelles at nano-bio interface. These nano-bio interactions are driven by colloidal forces and predominantly depend on the dynamic physicochemical and surface properties of nanomaterials. The book will include recent innovations of synthesis and atomic scale tailoring of various physical, biochemical sensing, other pharmaceuticals applications and surface properties of nanomaterials that are promising for dictating their interaction in an anticipated manner with biological entities for biomedical applications. However, toxicity and risks associated with engineered nanomaterials are gaining considerable attention, and the field of nanotoxicology is evolving promptly. Nanotechnology-enabled sensors and solutions are now able to detect and identify chemical or biological agents in the air and soil with much higher sensitivity than ever before. Therefore, this proposed book will explore current knowledge of articulate engineering of nanomaterials for biomedical applications with special attention on potential toxicological perspectives.

Topics to be addressed include:
• Next generation novel engineered materials synthesis and applications
• Novelty of biomedical application based research analysis and applications
• Unique attraction of industrialized bio-inspired materials applications
• A brand new technology of bio-sensor and microbial activities
• Exclusive nano imaging and cell culture activities and utilization
• Unique therapy of drug delivery applications


For inquries and proposals, contact Kaushik Pal, PhD at kaushikphysics@gmail.com

CONTENTS:
Tentative contents:

• Introduction to nanobiotechnology: recent advances.
• Nanomaterial-based bio-imaging as effective tool for the diagnosis of diseases.
• Antimicrobial abilities of metal oxide nanoparticles.
• Recent nanomaterial-based medications: opportunities and challenges.
• Antibiofilm activities of nanocomposites: current opportunities and limitations.
• Stem cell labeling and tracking using magnetic nanomaterials: overview.
• Nanomaterial-based bio scaffolds for enhanced biomedical applications.
• Highly-toxic nanomaterials for cancer treatment.
• Applications of nanomaterials in tissue engineering and regenerative medicine.
• Nanomaterials and personalized medicine: recent advances.


About the Authors / Editors:
Editors: Kaushik Pal, PhD
Research Professor, Department of Nanotechnology, and Founding Director of Center for Multidisciplinary Research Excellence (CMRE), Bharath University, Chennai, India


Gharieb Saied Saad El-Sayyad, PhD
Lecturer of Medical Microbiology and Nanotechnology, Drug Radiation Research Department, Atomic Energy Authority, Cairo, Egypt


Mohamed Abd Elkodous
Research Assistant, Center for Nanotechnology, Nile University, Giza, Egypt




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