Pharmaceutical Science & Technology

Drug Repurposing and Computational Drug Discovery
Strategies and Advances

Editor: Mithun Rudrapal, PhD

Drug Repurposing and Computational Drug Discovery

Published. Available now.
Pub Date: October 2023
Hardback Price: see ordering info
Hard ISBN: 9781774912775
E-Book ISBN: 9781003347705
Pages: 294 pp w/ index
Binding Type: Hardback / ebook
Notes: 12 color and 16 b/w illustrations

This new volume presents exciting recent advances in drug repurposing and computational approaches for the discovery and development of drugs against certain difficult-to-treat and life-threatening diseases, including microbial infections, parasitic diseases, brain disorders, and cancer. Drug repurposing is defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA approved drugs/pro-drugs, and the application of these newly developed drugs to the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research does not only help in the development of drugs from leads or existing drug molecules, but also can be of useful for the repurposing of existing drug candidates. This book is primarily aimed at delivering information on various computational techniques, tools, and databases being utilized for drug repurposing and for identifying the uses of existing drug candidates on different emerging or deadly diseases.

With contributions from a global team of experts (academicians, scientists, and researchers), this volume, Drug Repurposing and Computational Drug Discovery: Strategies and Advances, explores the sophisticated tools and techniques of drug repurposing and computational drug discovery. It provides up-to-date and in-depth information on the state-of-the-art strategies and techniques being utilized for the discovery of therapeutic candidates from existing natural leads, synthetic compounds, and/or drug molecules by experimental (in vitro, in vivo) as well as computational (in silico) techniques. Drug repurposing and computational approaches addressed in the book target the discovery and development of drugs for microbial infections (bacterial, fungal, viral, COVID-19), parasitic diseases and neglected tropical diseases (NTDs), malignant diseases (cancer), inflammatory diseases, cardiovascular disorders, diabetes, and aging and neurological (CNS) disorders. In addition, the challenges and regulatory issues encountered in drug repurposing and computational drug discovery programs are looked at, offering perspectives for future directions.

In addition, the challenges and regulatory issues encountered in drug repurposing and computational drug discovery programs are looked at, offering perspectives for future directions.

Key highlights of the book:

  • Presents cutting-edge strategies currently available in drug repurposing-based and computational drug discovery programs
  • Looks at potential advantages and clinical utilities of drug repurposing in the treatment of infectious illness, malignant diseases, and rare and difficult-to-treat diseases
  • Discusses drug discovery approaches using natural sources, phytochemicals, synthetic derivatives, existing drugs, or lead molecules by computational/database screening and experimental screening
  • Considers the legal regulations and ramifications of drug repurposing
The volume will be a useful resource to those working in the area of drug discovery and development research, such as drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, clinicians, R&D personnel, researchers, healthcare professionals students, teachers, and many others.

CONTENTS:
Preface

1. Drug Repurposing in Future Drug Discovery and Development
Kirti Agrawal, Malavika Saji, and Dhruv Kumar

2. Approaches, Strategies, and Advances in Computational Drug Discovery and Drug Repurposing
Tripti Sharma, Ipsa Padhy, and Chita Ranjan Sahoo

3. Drug Repurposing and Computational Drug Discovery for Viral Infections and Corona Virus Disease 2019 (COVID-19)
Siddhartha Maji, Vishnu Nayak Badavath, and Swastika Ganguly

4. Drug Repurposing and Computational Drug Discovery for Parasitic Diseases and Neglected Tropical Diseases (NTDs)
James H. Zothantluanga, Arpita Paul, Abd. Kakhar Umar, and Dipak Chetia

5. Drug Repurposing and Computational Drug Discovery for Malignant Diseases
Ashish Shah, Ghanshyam Parmar, and Ashish Patel

6. Drug Repurposing and Computational Drug Discovery for Inflammatory Diseases
Vishal Kumar Singh, Himani Chaurasia, Jayati Dwivedi, Richa Mishra, and Ramendra K. Singh

7. Drug Repurposing and Computational Drug Discovery for Cardiovascular Disorders
Johra Khan and Mithun Rudrapal

8. Drug Repurposing and Computational Drug Discovery for Diabetes
Manish Kumar Tripathi, Rahul Kumar Maurya, Alok Shiomurti Tripathi, and Mohammad Yasir

9. Drug Repurposing and Computational Drug Discovery for Aging and Neurological Disorders
Kumar Nallasivan Palani, Karthikeyan Deivasigamani, Sivasubramanian Piramanayagam, and Vishali Murthy

10. Challenges and Regulatory Issues in Drug Repurposing and Computational Drug Discovery
André M. Oliveira

Index


About the Authors / Editors:
Editor: Mithun Rudrapal, PhD
Associate Professor, Department of Pharmaceutical Sciences, School of Biotechnology & Pharmaceutical Sciences, Vignan’s Foundation for Science, Technology and Research (Deemed to be University), Guntur, India

Mithun Rudrapal, PhD, FIC, FICS, CChem (India), is Associate Professor at the Department of Pharmaceutical Sciences, School of Biotechnology & Pharmaceutical Sciences, Vignan’s Foundation for Science, Technology and Research (deemed to be University), Guntur, India. Dr. Rudrapal has been actively engaged in teaching and research the field of pharmaceutical and allied sciences for more than 12 years. He has over 100 publications in peer-reviewed international journals to his credit and has filed a number Indian and international patents. In addition, Dr. Rudrapal is the author of dozen published or forthcoming books. Dr. Rudrapal works in the areas of medicinal chemistry, computer-aided drug design (CADD), drug repurposing, phytochemistry, herbal drugs, and nanophytotherapeutics.




Follow us for the latest from Apple Academic Press:
Copyright © 2024 Apple Academic Press Inc. All Rights Reserved.