Medicine & Health Sciences

Drug Development for Cancer and Diabetes
A Path to 2030

Editors: K. Saravanan, PhD
Chukwuebuka Egbuna
Horne Iona Averal, PhD
S. Kannan, PhD
S. Elavarasi, PhD
Bir Bahadur, PhD

Drug Development for Cancer and Diabetes

Published. Available now.
Pub Date: August 2020
Hardback Price: see ordering info
Hard ISBN: 9781771888608
E-Book ISBN: 9780429330490
Pages: 392pp w/index
Binding Type: Hardback
Notes: 13 color and 32 b/w illustrations


Reviews
“This book extrapolates the recent advancements, emerging trends, and novel innovations and speculates about the future perspective in the discovery of drugs for the treatment of cancer and diabetes. As a complete package for the readers, this book provides a valuable window on the revolutionary sector of drug discovery. Part I and Part II of the book together provides comprehensive content to understand the theoretical aspect as well as practical advances and research discoveries. The novel approach of depicting the role of plants and the potential of phytochemi¬cals as antidiabetic and anticancer drugs is a key feature.”
—From the Foreword by Dr. P. Padmanabhan, Deputy Director, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

Drug Development for Cancer and Diabetes: A Path to 2030 focuses on new developments in the discovery of drugs for the treatment of cancer and diabetes. This new book presents important recent advances, emerging trends, and novel innovations for these two world-leading diseases. It is structured in two parts. Part I consists of chapters that explores cancer cell cycle checkpoints, cancer biomarkers, essential drug properties, stages in anti-cancer drug development, and various bioactives that are effective against cancer. Part II presents a complete coverage of important advances and research discoveries in antidiabetic drugs. It details the potentials of medicinal plants and phytocompounds as sources for antidiabetic drugs and highlights the ethnobotanical basis of the compounds.

With chapters written by professionals in the field of phytochemistry and pharmacology from key institutions around the world, this volume provides a wide coverage and will be useful especially for scientists in pharmaceutical field.

Key features:

  • Presents novel discoveries and mechanisms for the treatment of cancer and diabetes
  • Details the role of plants for the treatment and management of cancer and diabetes
  • Discusses the role of phytocompounds as ligands for cancer and diabetic targets
  • Reviews plants and the potential of phytochemicals as antidiabetic and anticancer drugs
  • Explores the green biosynthesis of nanoparticles and their efficiency in the treatment of diabetes and cancer

CONTENTS:
Preface

PART I: CANCER AND LEADS FOR CANCER TREATMENT
1. Biomarkers for Screening of Premalignant Lesions and Therapeutic Surveillance
Chukwuebuka Egbuna

2. Kinase Targets in Cancer Drug Discovery
S. Usha

3. Essential Drug Properties and Stages in Anti-Cancer Drug Development
Andrew G. Mtewa, Duncan Sesaazi, Annu Amanjot, and Serawit Deyno

4. Plant Constituents as Anti-Cancer Drugs
T. Veni, T. Pushpanathan, and G. Vimala

5. Anticancer Properties of Some Effective Phytochemicals
Murat Alan and Behnaz Aslanipour

6. Therapeutic Aspects of Some Extracts and Purified Cardiac Glycosides Obtained from Nerium oleander L.
Behnaz Aslanipour and Murat Alan

7. Challenging Compounds of Some Medicinal Plants against Cancer
N. Shaista Jabeen, L. Jagapriya, B. Senthilkumar, and K. Devi

8. Medicinal Plants as Therapeutic Agents in the Treatment of Cancer
Jaya Vikaskurhekar

9. Cytotoxic and Apoptosis-Inducing Effects and Anti-Cancerous Drug Candidature of Jasmonates
T. Parth, S. Ramalingam, T. Sampark, and T. Vasudev

10. Apoptosis Activity of 1, 2, Benzne Dicarboxylic Acid Isolated from Andrographis paniculata on KB, SiHa and IMR Cancer Cell Lines
P. Krishnamoorthy and D. Kalaiselvan

11. Anticancer Drug Discovery from the Indian Spice Box
M. V. N. L. Chaitanya, Santhivardhan Chinni, P. Ramalingam, and Y. Padmanabha Reddy

12. Phytochemical Investigation and Evaluation of Antibreast Cancer Activity of Chloroform Extract of Tagetes erecta
R. Arul Priya, K. Saravanan, and Chukwaebuka Egbuna

13. Isolation, Identification, and in Silico Evaluation of Anticancer Activity of Flavone from Pisum sativum
R. Arul Priya, K. Saravanan, and P. Karuppannan

14. Functional Lead Phytocheicals from the Rutaceae and Zingiferaceae Plants for Development of Anticancer Drugs
K. Saravanan, B. Umarani, V. Balan, P. Premalatha, and Bhir Bhadur

15. In Vitro Anticancer Activity of Biophytum sensitivum on Liver Cancer Lines (HepG2)
M. P. Santhi, K. Saravanan, and P. Karuppannan

16. Saffron and Its Active Ingredients: A Natural Product with a Potent Anticancer Property
Ashutosh Gupta and Abhay K. Pandey

PART II: ANTIDIABETIC DRUG DISCOVERY
17. Effects of Pterocarpus marsupium in the Management of Type 2 Diabetes Mellitus
Priscilla Suresh

18. Antidiabetic and Antihyperlipedemic Activities of Cyathea nilgiriensis (Holttum) on STZ-Induced Diabetic Rats
S. Elavarasi, G. Revathi, K. Saravanan, and horne Iona Averal

19. Antidiabetic Activity of Drug-Loaded Chitosan Nanoparticles
G. Revathi, S. Elavarasi, and K. Saravanan

20. Antidiabetic Activity of Silver Nanoparticles Biosynthesized Using Ventilago maderaspatana Leaf Extract
P. Karuppannan, K. Saravanan, and Horne Iona Averal

21. Hypoglycemic Activity of Biophytum sensitivum Whole Plant Extracts on Alloxan-Induced Diabetic Rats
C. Renuka, K. Saravanan, and P. Karuppannan

22. Antidiabetic Activity of Ventilago maderaspatana Leaf Extracts on STZ-Induced Diabetic Rats
P. Karuppannan, K. Saravanan, and P. Premalatha

23. Isolation, Identification, and Molecular Docking of Antidiabetic Compounds of Cytheia nilgiriensis (Holttum)
S. Elavarasi, G. Revathi, and K. Saravanan

24. Antidiabetic Potentials of Major Indian Spices: A Review
Pratibha, Hema Lohani, S. Zafar Haider, and Nirpendra K. Chauhan

25. Aloe Species: Chemical Composition and Therapeutic Uses in Diabetic Treatment
Amit Kumar Singh, Ramesh Kumar, B. Umarani, and Abhay K. Pandey

Index


About the Authors / Editors:
Editors: K. Saravanan, PhD
Associate Dean of Academic Affairs and Assistant Professor of Zoology, Nehru Memorial College, Puthanampatti, India

K. Saravanan, PhD, is Associate Dean of Academic Affairs and Assistant Professor of Zoology, Nehru Memorial College (Autonomous), an affiliated institution of Bharathidasan University, Tiruchirappalli, Tamilnadu, India. He has been engaged in teaching and research for over 15 years. He has guided PhD and MPhil scholars, and several are at present scholars are working under his guidance in the field of environment and natural drug research. He has published research papers, book chapters, and a book. He is currently editing two books with Elsevier and Astral Publishers. He is a reviewer for various journals, including the Indian Journal of Experimental Biology, Journal of Threatened Taxa, and Journal of Medicinal Plant Research. He is an editorial member of the Indian Journal of Natural Science and his university’s college magazine, The Rose. He has edited conference abstracts and one conference proceedings. Dr. Saravanan is a recipient of Har Gobind Khorana Best Scientist Award given by the Bose Science Society, Pudukottai, Tamilandu, India. He has completed one major research project and organized national and international conferences as well as several state-level workshops with financial assistance of various funding agencies. His fields of interest are natural drug development, rodent pest management, and ecology.

Chukwuebuka Egbuna
Research Biochemist, Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria

Chukwuebuka Egbuna is a chartered chemist, a chemical analyst, and an academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), the Society of Quality Assurance (SQA) (USA), and the Royal Society of Chemistry (RSC) (United Kingdom). He has been engaged in a number of roles at New Divine Favor Pharmaceutical Industry Limited, Akuzor Nkpor, Anambra State, Nigeria, and Chukwuemeka Odumegwu Ojukwu University (COOU), Nigeria. He has collaboratively worked and published quite a number of research articles in the area of phytochemistry and its applications. Mr. Egbuna has edited a 3-volume set book of phytochemistry with Apple Academic Press (Phytochemistry, Volume 1: Fundamentals, Modern Techniques, and Applications; Phytochemistry, Volume 2: Pharmacognosy, Nanomedicine, and Contemporary Issues; and Phytochemistry, Volume 3: Marine Sources, Industrial Applications and Recent Advances). He is also working on other books with Elsevier and Springer Nature. He is a reviewer and editorial board member of various journals, with his most recent role as a website administrator for the Tropical Journal of Applied Natural Sciences (TJANS), a journal of the faculty of Natural Sciences, COOU. His primary research interests are in phytochemistry, food and medicinal chemistry, analytical chemistry, and nutrition and toxicology.

Horne Iona Averal, PhD
Dean of Science, Associate Professor of Zoology, Holy Cross College, Trichy, Tamilnadu, India

Horne Iona Averal, PhD, is an Associate Professor at Holy Cross College, Trichy, India. She has been honored with the Gobind Khorana Best Scientist Award and the Fellow of Bose Science Society Award. Also, she is a recipient of many other awards and honors, including a gold medal for best research paper from an international symposium. She has been engaged with many academic roles in her home institution and other institutions and universities. She is a member of academic bodies at 21 different colleges. Dr. Averal is a life member of the Bose Science Society and the Society of Reproductive and Comparative Endocrinology. She is an active reviewer of the British Journal of Medicine and Medical Research. She has undertaken major and minor research projects relevant to anti-repellency and polycystic ovary. Dr. Averal has published four nucleotide sequences in the NCBI-GENBANK and has developed many e-lessons in the area of metabolic disorders, genetic disorders, and gene therapy.

S. Kannan, PhD
Professor and Head, Department of Zoology, Periyar University, Salem, Tamil Nadu, India

Soundarapandian Kannan, PhD, is a specialist in cancer biology and nanomedicine. He has been engaged in a number of roles at national and international academic and scientific bodies. He has collaboratively worked and published a large number of research articles in the area of nanomedicines related to cancer. Dr. Kannan has published four sets of books relevant to molecular biology and cancer therapy and is a reviewer in six different journals. His recent studies have demonstrated the presence of a target for the development of therapeutic agents for lung and breast cancers, namely cytosolic phospholipase A2 (cPLA2 ) and cycloxiginase. Secondly, he has performed target validation for cPLA2 and COX2 with a view to the development of highly specific, tumor-directed anticancer drug vehicles such as enzyme inhibitors and enzyme-targeted prodrugs, namely Pyrrolidine-2 and Doxorubicin loaded antibody dependent nanoparticles, etc. He has also formulated multifunctional magnetic polymers nano-combinations, which are gaining wide recognition in cancer nanotheranostics due to their safety and their potential in delivering targeted functions. M/S Sigma Aldrich has provided citations for his methodologies to extract products, such as sandal wood oil/natural oil, Fucoidan, R-Phycoerythrin, and application of 1-aminoanthracene.

S. Elavarasi, PhD
Assistant Professor, PG and Research Department of Zoology, Holy Cross College (Autonomous), Tiruchirappalli, Tamilnadu, India

S. Elavarasi, PhD, is an Assistant Professor at Holy Cross College, an affiliated institution of Bharathidasan University, Tiruchirappalli, Tamilnadu, India. She has been engaged in teaching and research for more than eight years. She was awarded a NTS-PhD fellowship–2010 by the Central Institute Indian Languages, Mysore, Karnataka, India, for pursuing her PhD degree. She has also awarded National Post Doctoral Fellowship–2016 by SERB-DST, New Delhi, India. She has collaboratively worked and published 25 research articles in various fields of life sciences. She also published two book chapters and a book. She has edited a conference souvenir. Her primary research interests are herbal technology and drug designing.

Bir Bahadur, PhD
Professor (Retired), Former Chairman and Head of the Department, Dean of the Faculty of Science, Kakatiya University, Warangal, India

Bir Bahadur, PhD, was formerly Professor, Chairman, and Head of the Department, as well as Dean of the Faculty of Science at Kakatiya University in Warangal, India, and has also taught at Osmania University in Hyderabad, India. During his long academic career, he was honored with the Best Teacher Award by the Andhra Pradesh State Government for mentoring thousands of graduate and postgraduate students, most of whom went on to occupy high positions at various universities and research organizations in India and abroad. Dr. Bahadur has been the recipient of many awards and honors, including the Prof. Vishwambar Puri Gold Medal from the Indian Botanical Society for his original research contributions in various aspects of plant sciences. He is listed as an Eminent Botanist of India and is a BharathJyoti Awardee for his sustained academic and research career at New Delhi, India. Long active in his field, he is a fellow and member of over dozens professional bodies in India and abroad. He is a Fellow of the Linnean Society (London); Chartered Biologist & Fellow of the Institute of Biology (London); Member of the New York Academy of Sciences; Recipient of the Royal Society Bursary and Honorary Fellow of Birmingham University (UK); among others. He was an Independent Director at Sri Biotech Laboratories India, Ltd., Hyderabad, India, for several years. Professor Bahadur has published over 250 research papers in national and international journals as well as reviews, book chapters, and several books. He has been an invited speaker at over 120 national and international conferences and has served as Chief Editor of Proceedings of Andhra Pradesh Akademi of Sciences and the Journal of Palynology. A member of editorial boards of several national and international journals, he has made significant contributions in several areas of plant biology, especially in heteromorphic incompatibility, genetics, mutagenesis, morphogenesis, plant tissue culture and biotechnology, plant asymmetry and handedness, and the application of SEM pollen and seeds in relation to systematic and medicinal plants. He has supervised many PhD theses and has taught genetics, biotechnology, plant molecular biology, plant reproduction, and related subjects for over 45 years and has accumulated research experience in these areas for 50 years.




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