Medicine & Health Sciences

Cystic Fibrosis
Disease Management and Advanced Drug Delivery Systems

Editors: Bhupendra Prajapati, PhD
Rishabha Malviya, PhD
Sonali Sundram, PhD
Akshay Parihar

Cystic Fibrosis

In Production
Pub Date: Forthcoming October 2025
Hardback Price: $240 US | £180 UK
Hard ISBN: 9781779640406
Pages: Est. 424pp w/index
Binding Type: Hardback / ebook
Notes: 16 color and 24 b/w illustrations


Reviews
“A comprehensive exploration of the condition and the cutting-edge therapeutic options being developed for the management of cystic fibrosis. . . . a quality book on cystic fibrosis management.”
—From the Foreword by Dr. Dhruv Galgotia, CEO, Galgotias University, Greater Noida, India


This new volume explores the most recent research, therapeutic developments, and clinical techniques used in treating cystic fibrosis, a potentially fatal genetic illness that affects the lungs and digestive system, resulting in severe respiratory and gastrointestinal difficulties. The volume provides an in-depth discussion of the disease pathogenesis, the critical role of microbes in its progression, and cutting-edge techniques for combating it.

The book begins by providing an overview of cystic fibrosis, including its genetic foundation, clinical manifestations, and severe impact on patients lives. The book further addresses the complex pathophysiology components of the condition, providing insight into the disruptions induced by cystic fibrosis transmembrane conductance regulator (CFTR) mutations. The book also discusses the role of microbial infections in aggravating cystic fibrosis, emphasizing the need for appropriate infection control and management.

The book explores novel therapeutic techniques to address cystic fibrosis, including gene therapy and personalized medicine, as well as novel delivery systems such as liposomes, lipid nanoparticles, and polymeric nanoparticles to revolutionize cystic fibrosis treatment. It also explains the use of aerosol antibiotics and anti-inflammatory medicines to treat respiratory problems and inflammation.

This book will be informative for a wide range of readers, including doctors, researchers, healthcare professionals, and students interested in improving our understanding and treatment strategies for cystic fibrosis.

CONTENTS:
Foreword by Dhruv Galgotia

Preface

1. Introduction to Cystic Fibrosis

Lucy Mohapatra, Deepak Mishra, Alok Shiomurti Tripathi, Alka Kumari, Sambit Kumar Parida, and Bhupendra G. Prajapati

2. Pathophysiological Aspects of Cystic Fibrosis
Sarika Kamble, Akshada Kale, Kishori Ahire, Kalpesh Patil, and Aman Upaganlawar

3. The Role of Microorganisms in Causing Cystic Fibrosis
Neelakanta Sarvashiva Kiran, Chandrashekar Yashaswini, and Bhupendra G. Prajapati

4. Novel Therapeutic Approaches for Cystic Fibrosis
Bhavarth P. Dave, Mehul R. Chorawala, Shivam U. Bhagat, Nidhi N. Shah, Bhupendra G. Prajapati, Priyajeet S. Parekh, and Rakesh B. Patel

5. Cystic Fibrosis: Disease and Advanced Drug Delivery Systems
Ravish J. Patel, Bhupendra G. Prajapati, Nidhi Trivedi, Vidhi Pandya, Amit A. Patel, Samir G. Patel, and Archita Patel

6. Lipid-Nanoparticles in Treating Cystic Fibrosis
Devesh U. Kapoor, Bhumi T. Bhatt, Deepak Sharma, Dhiren P. Shah, Bhupendra G. Prajapati, Sudarshan Singh, and Henis Patel

7. Regulations for Monitoring and Management of Cystic Fibrosis
Shivani N. Jani, Hitesh B. Katariya, and Bhupendra G. Prajapati


8. Aerosol Antibiotics in Management of Cystic Fibrosis
Amol D. Gholap, Pankaj R. Khuspe, Deepak K. Bharati, Swapnil Ghorpade, Bhupendra G. Prajapati, and Md Faiyazuddin

9. Polymeric Nanoparticles in Treating Cystic Fibrosis
Shubhrat Maheshwari, Aditya Singh, Bhupendra G. Prajapati, Vijayshwari Mrityunjay Mishra, and Shivangi Dwivedi

10. Medical Devices Used in Cystic Fibrosis
Abin V. Geevarghese and Bhupendra G. Prajapati

11. Anti-Inflammatory Agents Used in Cystic Fibrosis
Swati Pal, Jasveer Kaur, Roshmi Ray, Sushant, Bhupendra G. Prajapati, Akshay Parihar, Himanshu Paliwal, and Venkatanarayana Pappula

12. Challenges for Development of Formulation in Cystic Fibrosis
Sourav Mohanto, Amol D. Gholap, Pankaj R. Khuspe, Navnath T. Hatvate, Sadikali F. Sayyad, Machindra J. Chavan, Mohammed Gulzar Ahmed, Md. Faiyazuddin

13. Epigenetic Modifications in CFTR Regulation, Gene Expression and its Impact on Cystic Fibrosis Development
Shama Mujawar, Sabyasachi Banerjee, Rutuja Bhoite, and Bhupendra Prajapati

14. Heart Failure in Cystic Fibrosis: Treatment and Prognosis
Pratik Thakkar and Akshay Parihar

15. Diagnostic Tools for Cystic Fibrosis
Suchita Waghmare, Rohini Palekar, Lata Potey, Pratiksha Bramhe, Nilesh Rarokar, Pramod Khedekar, Prafulla Sabale, Vidya Sabale, and Bhupendra Prajapati

Index


About the Authors / Editors:
Editors: Bhupendra Prajapati, PhD
Professor, Department of Pharmaceutics, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India

Bhupendra Prajapati, PhD, is a Professor in the Department of Pharmaceutics at the Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India. He has more than 22 years of academic and research experience and has published more than 250 research and review papers in international and national journals. Under his editorship, five books has been published, and eight book are in progress. He has authored 150 book chapters in the field of novel drug delivery and has published two Indian patents, with another three applications under evaluation. He is a reviewer for high-impact journals and is on the editorial boards of several scientific journals.

Rishabha Malviya, PhD
Associate Professor, School of Medical & Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India

Rishabha Malviya, PhD, is working as Associate Professor in the Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, India. He has 12 years of research experience. His area of interest includes formulation optimization, nanoformulation, targeted drug delivery, localized drug delivery, and characterization of natural polymers as pharmaceutical excipients. He has authored more than 200 research/review papers for national/international journals of repute. He has 58 patents (19 grants, 38 published, one filed) and many publications in reputed national and international journals. He has received an Outstanding Reviewer Award from Elsevier. He has authored and edited 48 books (Wiley, CRC Press/Taylor and Francis, Springer, River Publisher, IOP Publishing, and OMICS Publishing Group) and authored over 30 book chapters. His name has included in the World Top 2% Scientists list by Stanford University. He is a reviewer, editor, and editorial board member for more than 50 national and international journals of repute. He was an invited author for the magazine Atlas of Science as well as a pharma magazine dealing with B2B industry, Ingredient South Asia. He completed his BPharm at Uttar Pradesh Technical University and MPharm (Pharmaceutics) at Gautam Buddha Technical University, Lucknow Uttar Pradesh, India. His PhD (Pharmacy) work was in novel formulation development techniques.

Sonali Sundram, PhD
Assistant Professor, School of Medical & Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India

Sonali Sundram, PhD, is Assistant Professor in the School of Medical & Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India. She previously worked as research scientist in a project of the Indian Council of Medical Research at King George Medical University, Lucknow, India. After that, she joined BBDNIIT (Babu Banarasi Das Northern India Institute of Technology), Lucknow. Her PhD (Pharmacy) work was in the area of neurodegeneration and nanoformulation. Her area of interest is neurodegeneration, clinical research, and artificial intelligence. She has authored and edited more than 15 books (Wiley, CRC Press/Taylor and Francis, IOP Publishing, Apple Academic Press/Taylor and Francis, Springer Nature, and River Publisher). She has attended and organized more than 15 national and international seminars, conferences, and workshops. She has more than eight patents national and international to her credit. She has published six SCI-indexed manuscripts with reputed international publishers. She has delivered oral presentations at international conferences organized in different European countries. She completed both here BPharm and MPharm (Pharmacology) at Dr. A.P.J. Abdul Kalam Technical University, Lucknow, India.

Akshay Parihar
Assistant Professor, Faculty of Pharmaceutical Sciences, Institute of Chartered Financial Analysts of India University, Himachal Pradesh, India

Akshay Parihar works as an Assistant Professor in the Faculty of Pharmaceutical Sciences, Institute of Chartered Financial Analysts of India University, Himachal Pradesh, India. He is pursuing his PhD at Ganpat University, Mehsana, Gujarat. He earned his MPharm (Pharmaceutics) and BPharm degrees from Bhupal Nobles University, Udaipur, and Rajasthan University of Health Sciences, Jaipur, respectively. He completed an Advanced Post Graduate Program in Clinical Research and Management at Clini India, Pune, and has five years of working experience in academics. He is actively working on novel drug delivery system development and optimization for the increasing solubility of BCS class IV drugs to treat cystic fibrosis.




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